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Bupropion XL is an FDA-approved medication for the treatment of major depressive disorder (MDD) and seasonal affective disorder (SAD).
Approved by the FDA in 2003, Bupropion has helped countless people reclaim their focus, energy, and emotional balance.
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Bupropion XL is an extended-release medication used to treat depression, seasonal affective disorder (SAD), and help with quitting smoking. It works by balancing dopamine and norepinephrine—two key brain chemicals linked to motivation, focus, and mood. This makes it a great option for people dealing with low energy or loss of interest, along with depression.
Unlike many other antidepressants, Bupropion XL doesn’t typically cause weight gain or sexual side effects. And since it’s extended-release, it only needs to be taken once a day.
Take Bupropion XL once daily in the morning, with or without food. Swallow the tablet whole—don’t crush or split it. It’s important to take it at the same time each day for consistent results.
Your doctor will usually start you at 150mg and may increase to 300mg based on how you respond. Don’t take more than prescribed—higher doses increase the risk of seizures.
Most people tolerate Bupropion XL well. Common side effects can include dry mouth, trouble sleeping, sweating, or mild anxiety, especially when starting out. These often improve with time.
Serious side effects are rare but can include increased blood pressure or, in rare cases, seizures. Avoid drinking heavily while on Bupropion, as this raises seizure risk. If you experience mood changes, agitation, or unusual thoughts, reach out to your provider right away.
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Bupropion XL is a trusted, long-acting antidepressant that helps with symptoms of depression, seasonal affective disorder (SAD), and even helps some people quit smoking. It's different from many other antidepressants—it works on dopamine and norepinephrine, which can improve motivation, energy, and focus. That makes it a solid choice if you’re feeling low, sluggish, or unmotivated.
Unlike some antidepressants, Bupropion XL is less likely to cause weight gain, sexual side effects, or drowsiness. It’s taken just once daily, making it simple to stick with.
The typical starting dose is 150mg once daily in the morning. Depending on how your body responds and your doctor’s guidance, the dose may be increased to 300mg once daily after a few days.
Never take more than what your provider recommends. Taking too much Bupropion can raise the risk of seizures, especially if you have a history of certain medical conditions or are prone to dehydration or alcohol use.
Yes, as long as you get it through a legitimate, licensed provider like MailMyMeds. You’ll complete an online health evaluation reviewed by a licensed healthcare professional before receiving a prescription.
Avoid buying Bupropion from unverified sources or websites that don’t require a prescription. That can be unsafe and even illegal.
Bupropion XL works by affecting two key brain chemicals—dopamine and norepinephrine. These play a role in mood, energy, focus, and motivation. By balancing these chemicals, Bupropion helps relieve symptoms of depression and low mood.
It also reduces nicotine cravings and withdrawal symptoms, which is why it's used to help people quit smoking.
Because it's an extended-release formula, Bupropion XL works throughout the day with just one pill, helping you feel more stable and balanced over time.
Avoid drinking large amounts of alcohol, as it can increase the risk of seizures when combined with Bupropion. You should also avoid taking other forms of Bupropion at the same time (like Wellbutrin IR or SR) unless prescribed.
Let your doctor know if you’re taking other medications for depression, anxiety, or sleep, as combining certain drugs can cause side effects or interactions.
Also, avoid suddenly stopping the medication without medical guidance—tapering off gradually is often recommended.
No, Bupropion is a prescription-only medication. It’s important to have a healthcare provider review your symptoms and medical history before starting it.
With MailMyMeds, you can complete the consultation process entirely online. If appropriate, a licensed provider will issue a prescription and have it shipped discreetly to your door.
Always follow the instructions from your healthcare provider. If you notice anything unusual—like changes in mood, trouble sleeping, or increased anxiety—reach out to your provider right away.
