When it comes to treating erectile dysfunction (ED), most men eventually find themselves comparing Cialis vs Viagra. Both are FDA-approved, both work well for most men, and both belong to the same class of medications known as phosphodiesterase type 5 inhibitors (PDE5 inhibitors).
Yet despite their similarities, Viagra vs Cialis differ in how long they last, when they start working, and even how they make you feel. For some men, Cialis vs Viagra price per tablet can also be a deciding factor when choosing between them.
If you’ve ever wondered which one is better for you, this is the only Viagra vs Cialis guide you’ll ever need.
If you’re still learning about what causes ED and how it’s diagnosed, you can read our full guide on the signs, symptoms, and treatment for erectile dysfunction before diving deeper into how these medications compare.
How Viagra and Cialis Work
Both Viagra (sildenafil) and Cialis (tadalafil) work by blocking an enzyme called PDE5, which allows blood to flow more easily into erectile tissue during sexual stimulation. In plain terms, they help you get and maintain an erection when you’re aroused. They don’t create arousal themselves, and you still need to be in the mood for them to work. 1 2
When comparing Viagra vs Cialis, it is important to know that they share the same basic mechanism, but the way your body handles each drug is different. Viagra tends to act faster but fades within a few hours, while Cialis takes effect at a similar speed but lasts much longer. 3
Cialis Daily vs As-Needed Use
This is where the Cialis vs Viagra difference becomes clearer. Cialis is the only ED medication approved for daily use. Men who take it daily at lower doses (2.5 to 5 mg) maintain consistent levels in their system, which can lead to steady, predictable results. Daily dosing is often preferred by men who have sex more than a few times a week or who don’t want to plan around a medication. 4
Taking Cialis daily can also reduce the intensity of side effects since the amount absorbed at one time is smaller. Viagra doesn’t have a daily-use version, so it’s usually taken as needed before sex. Your choice between daily and as-needed treatment depends on how often you’re sexually active and what feels easiest to manage. 1
Comparing Viagra vs Cialis Onset and Duration
When it comes to timing, Viagra and Cialis work in slightly different ways:
- Viagra usually starts working within 30 to 60 minutes and lasts around 4 to 5 hours.
- Cialis kicks in after about 30 to 45 minutes but stays active in the body much longer, up to 24 to 36 hours. That’s why people often call it the “weekend pill.” 3
The long duration of Cialis means you don’t have to plan as carefully because you can take it in the morning, and it’ll still work in the evening. Viagra, with its shorter window, is better suited for men who prefer to take a pill only when they know they’ll need it.
Essentially, Viagra offers quick, short-term results, while Cialis provides flexibility and spontaneity. Your choice depends on your personal preference.
Cialis vs Viagra Effectiveness: Which One Works Better?
When it comes to effectiveness, both drugs perform extremely well. Studies show that:
- Viagra helps around 69% of men achieve and maintain an erection suitable for sex.
- Cialis performs similarly, with success rates around 81% depending on dosage and severity of ED.
However, what sets Cialis apart is its duration and flexibility. In several head-to-head studies, most men who tried both drugs preferred Cialis largely because they didn’t have to plan around it. One trial found that 69% of men favored Cialis for its longer window of opportunity.
Ultimately, there’s no universal “better” option. Viagra vs Cialis comparisons come down to how your body reacts and what fits your habits.
Cialis vs Viagra: Side Effects
When looking at Cialis vs Viagra side effects, some reactions are shared between the two, while others are unique to each medication.
Common side effects include:
- Headache
- Flushing
- Upset stomach
- Nasal congestion
- Muscle pain 3
Rare side effects (seek immediate care):
Some differences in Cialis vs Viagra side effects stand out between the two medications. These include:
- Cialis-specific effects: Muscle aches (likely from PDE11 cross-reactivity) were seen in 3% of men in clinical trials.
- Viagra-specific effects: Temporary visual changes, like changes in color perception (due to its interaction with PDE6), were seen in 1% of men in clinical trials. 4
When looking at Cialis vs Viagra side effects, both drugs usually cause mild, temporary reactions. 3 The right choice often comes down to how your body responds and what feels comfortable for you. For some men, Cialis vs Viagra side effects end up being the deciding factor after trying both.
The main takeaway from comparing Cialis vs Viagra side effects is that some men find one medication easier to tolerate than the other. It’s not that one drug is necessarily riskier; it’s that everyone’s body reacts differently, and one option may feel more comfortable than the other.
That said, if you notice any side effects that bother you or don’t go away, it’s best to check in with your doctor so they can adjust your treatment if needed.
Interactions and Safety
Cialis and Viagra can cause a temporary drop in blood pressure, so they should never be taken with prescription drugs that contain nitrates. Nitrates that occur naturally in food are usually safe. 3
You should also use caution if you take other medications that lower blood pressure. Alpha blockers such as tamsulosin (Flomax) and alfuzosin (Uroxatral), which are often prescribed for prostate enlargement, can sometimes cause blood pressure to fall. 3
Always tell your doctor about all the medications, supplements, and over-the-counter products you use, as well as your full medical history. This helps your provider determine whether ED treatment is safe for you and whether any adjustments are needed to prevent dangerous interactions.
Cialis vs Viagra: Price Comparison
Medication cost matters, especially since ED pills can get pricey over time. When comparing Cialis vs Viagra price per tablet, the difference can influence which option makes more sense for long-term use. At MailMyMeds, pricing for a 20-tablet supply is as follows:
| Cialis vs Viagra Price Per Tablet (20 Tablet Supply) | ||
| Medication | Strength (mg) | Price Per Tablet (USD) |
| Viagra | 20 | 2.10 |
| 25 | 2.10 | |
| 50 | 2.25 | |
| 100 | 2.25 | |
| Cialis | 2.5 | 2.10 |
| 5 | 2.10 | |
| 10 | 2.25 | |
| 20 | 2.25 | |
+ Based on cost information from MailMyMeds
If you buy larger quantities of medication, the price per tablet decreases. That’s especially helpful if you’re on daily Cialis or if you take Viagra frequently.
When comparing Cialis vs Viagra price per tablet, it really depends on how you use it. For occasional use, Viagra tends to be the more affordable option since you only take it when needed. But if you prefer daily dosing or want the freedom to be spontaneous, Cialis usually offers better long-term value.
Conclusion
When comparing Cialis vs Viagra, the choice really comes down to timing, tolerance, and personal preference. Both are safe, effective, and well-studied options for treating erectile dysfunction. Cost also plays a role. Comparing Cialis vs Viagra price per tablet, alongside convenience and comfort, helps you make a realistic decision.
If you’re deciding between Viagra vs Cialis, it’s worth remembering that your lifestyle often determines which works best for you, rather than one being objectively stronger or longer-lasting. If you want something reliable and short-acting, Viagra fits the bill. If you value flexibility and less planning, Cialis is worth considering. For most men, the best option comes after some trial and error under the supervision of a doctor.
For more guidance on managing erectile dysfunction, improving performance anxiety, or understanding relationship impacts, check out related posts on our ED blog.
The content in this article is intended for informational purposes only. This website does not provide medical advice. In all circumstances, you should always seek the advice of your physician and/or other qualified health professionals(s) for drug, medical conditions, or treatment advice. The content provided on this website is not a substitute for professional medical advice, diagnosis, or treatment.
